Advanced MRI - M267 Problem Set 4

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gamma = 42.58 MHz/Tesla = 4258 Hz/gauss

fat/water chemical shift = 3.5 ppm

Problem 1

Assume that the figure above shows the timing of a readout gradient in an MR sequence, scaled to unit amplitude at TE, which occurs at the time 6t in the center of the readout period, and that the dashed line represents zero gradient amplitude. The period indicated in blue is the readout. Find the amplitude 'A' such that the sequence produces zero net phase shift for stationary, constant velocity, and accelerating spins. See Motion artifacts in MRI for help.

A= (unitless multiples of the readout gradient amplitude)

Problem 2

If we keep chemical shift artifact constant (e.g., one pixel between fat and water):

at 0.5 Tesla at 1.5 Tesla
What is the frequency/pixel in readout? Hz Hz
Relative SNR between 0.5T and 1.5T? (unitless SNR ratio)

Problem 3

Which of the following are reasons that spectroscopy is best done at higher magnetic fields (check as many as are correct)?

The chemical shift (ppm) between molecules is increased The larger magnetization results in improved SNR
The 'J' coupling results in broader splitting Chemical shifts are larger compared to local field distortions
The acquisition times are shorter for constant SNR High field instruments are easier to shim
The increased shift (in Hz) results in a lower readout bandwidth and improved SNR The increased RF power results in better excitation homogeneity

Problem 4

True or False: in vivo MR Spectroscopy can provide reliable absolute measures of solute concentrations.

Problem 5

Check all that are true as imaging time is decreased in EPI:

SNR decreases with the 1/square root of the total readout duration Required Gradient Power decreases
Chemical Shift artifact decreases Motion artifact is decreased
Achievable Spatial Resolution Decreases Specific Absorptoin Rate (SAR) is reduced
Magneto-Stimulation becomes more likely Shape Distortions Increase

Problem 6

Which MR angiographic sequence (check all that are true):

Is Quantitative for flow velocity Time-of-flight (saturation) Phase Contrast
Uses spatial presaturation to detect flow direction Time-of-flight (saturation) Phase Contrast
Is more effective at short TR Time-of-flight (saturation) Phase Contrast
Requires six excitations to measure 3D flow Time-of-flight (saturation) Phase Contrast

Problem 7

Explain the changes in conspicuity of small features at low contrast when field of view is reduced.

Problem 8

Why does Turbo-FLASH require a contrast preparation pulse, while EPI does not?

Problem 9

The "Ernst Angle" is (check all that are true):

acos(exp(-tr/T1)) The angle at which the MR signal is greatest for a given tr and T1
Increases with TR The excitation angle giving the greatest Signal given te and T2
sin(-tr/t1) Usually larger at High field

Please feel free to contact me or Michael Zeineh with questions.

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©11/20/02 Mark S. Cohen, Ph.D.